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ASSAYS TO PREDICT ATHEROSCLEROSIS AND DYSFUNCTIONAL HIGH-DENSITY LIPOPROTEIN
ASSAYS TO PREDICT ATHEROSCLEROSIS AND DYSFUNCTIONAL HIGH-DENSITY LIPOPROTEIN
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机译:预测动脉粥样硬化和功能障碍的高密度脂蛋白的测定
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摘要
This invention provides novel assays for the detection of dysfunctional HDL. The assays are good diagnostics and/or prognostics for atherosclerosis or other pathologies characterized by an inflammatory response. In certain embodiments the methods involve measurements of heme-related HDL-associated proteins (e.g., haptoglobin, hemopexin, etc.), and/or measurements of the relative distribution of HDL-associated proteins between HDL and the non-lipoprotein fractions of plasma/serum, and/or measurements of the ability of pro-inflammatory HDL to consume nitric oxide, and/or measurement of the ability of HDL to inhibit LDL aggregation.
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