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MONOCLONAL ANTI MINICHOMOSOME MAINTENANCE 2 PROTEIN ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE
MONOCLONAL ANTI MINICHOMOSOME MAINTENANCE 2 PROTEIN ANTIBODIES AND METHODS FOR THEIR USE IN THE DETECTION OF CERVICAL DISEASE
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机译:单克隆抗微小染色体维持2蛋白抗体及其在检测宫颈疾病中的用途
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摘要
Compositions and methods for diagnosing high-grade cervical disease in a patient sample are provided. The compositions include monoclonal antibodies, and variants and fragments thereof, that specifically bind to MCM2. Monoclonal antibodies having the binding characteristics of an MCM2 antibody of the invention are further provided. Hybridoma cell lines that produce an MCM 2 monoclonal antibody of the application are also disclosed herein. The compositions find use in practicing methods for diagnosing high-grade cervical disease comprising detecting overexpression of MCM2 in a cervical sample from a patient. Kits for practicing the methods of the application are further provided. Polypeptides comprising the amino acid sequence for an MCM2 epitope and methods of using these polypeptides in the production of antibodies are also encompassed by the present application.
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