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INHIBITION OF UBC9-MEDIATED CANCER CELL INVASION AND METASTASIS

机译：抑制UBC9介导的癌细胞侵袭和转移

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摘要

A method for inhibiting invasion or metastasis of cancer cells that contemplates enhancing the expression of miR-224 in those cells, particularly human breast cancer ceils is disclosed. The production of miR-224 can be enhanced by suppressing the expression of Ubc9 in rhose cancer cells. Expression of Ubc9 can be suppressed by administering to those cancer cells an effective amount of antisense Ubc9 having a sequence complementary to a portion of the coding region or a non-coding region of Ubc9 mRNA and has a length of 10 to about 170 bases.

机译：公开了一种抑制癌细胞侵袭或转移的方法，该方法旨在增强这些细胞特别是人类乳腺癌细胞中 miR-224 的表达。 miR-224 的产生可通过抑制Ubc9在玫瑰果癌细胞中的表达来增强。通过向那些癌细胞施用有效量的反义Ubc9可以抑制Ubc9的表达，所述反义Ubc9具有与Ubc9 mRNA的编码区或非编码区的一部分互补的序列，并且长度为10至约170个碱基。 展开▼

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公开/公告号WO2011084815A1

专利类型

公开/公告日2011-07-14

原文格式PDF

申请/专利权人 BOARD OF TRUSTEES OF SOUTHERN ILLINOIS UNIVERSITY;MO YIN-YUAN;
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申请/专利号WO2010US61622

发明设计人 MO YIN-YUAN;
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申请日2010-12-21

分类号C12N15/11;

国家 WO

入库时间 2022-08-21 17:56:42

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