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Method for characterizing reversible association of macromolecules in solution at high concentration
Method for characterizing reversible association of macromolecules in solution at high concentration
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机译:高浓度溶液中大分子可逆缔合的表征方法
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摘要
A new method is presented for characterizing the associative properties of a solution of macromolecules at high concentration. Sample aliquots spanning a range of concentrations are injected sequentially into a light scattering photometer. Equilibrium association constants and association stoichiometry are derived from an analysis of the angular and concentration dependence of the scattering signals. Thermodynamic nonideality, which becomes important at high concentrations, is dealt with in the analysis in a simplified manner which is applicable to multiple associated species.
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