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Systematic Investigation of Factors Affecting the Viscosity and Self-Association Issues in High Concentration Monoclonal Antibody Solutions

机译：系统研究高浓度单克隆抗体溶液中粘度和自缔合问题的影响因素

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作者
Yadav, Sandeep;
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作者单位

University of Connecticut;

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授予单位 University of Connecticut;
学科
学位 Ph.D.
年度 2010
页码 276 p.
总页数 276
原文格式 PDF
正文语种 eng
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专利

1. Reversible self-association of a concentrated monoclonal antibody solution mediated by Fab-Fab interaction that impacts solution viscosity. [J] . Kanai S, Liu J, Patapoff TW, Journal of pharmaceutical sciences. . 2008,第10期

机译：通过影响溶液粘度的Fab-Fab相互作用介导的浓缩单克隆抗体溶液的可逆自缔合。
2. Factors affecting the viscosity in high concentration solutions of different monoclonal antibodies. [J] . Yadav S, Shire SJ, Kalonia DS Journal of pharmaceutical sciences. . 2010,第12期

机译：影响不同单克隆抗体高浓度溶液中粘度的因素。
3. The influence of charge distribution on self-association and viscosity behavior of monoclonal antibody solutions [J] . YadavS., LaueT.M., KaloniaD.S., Molecular pharmaceutics . 2012,第4期

机译：电荷分布对单克隆抗体溶液的自缔合和粘度行为的影响
4. Absolute quantification of monosaccharide concentrations in a monoclonal antibody (IgG) using acid hydrolysis and ID LC-MS/MS [C] . Mark S. Lowentha, Eric Kilpatrick, John Schiel, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：使用酸水解和ID LC-MS / MS的单克隆抗体（IgG）中单糖浓度的绝对定量
5. Self-association, crystallization, and phase separation: Understanding intermolecular interactions for a monoclonal antibody. [D] . Cromwell, Mary Ellen Miley. 2008

机译：自缔合，结晶和相分离：了解单克隆抗体的分子间相互作用。
6. In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions [O] . Dheeraj S. Tomar, Li Li, Matthew P. Broulidakis, 2017

机译：单克隆抗体溶液浓度依赖性粘度曲线的计算机模拟预测
7. How Well Do Low- and High-Concentration Protein Interactions Predict Solution Viscosities of Monoclonal Antibodies? [O] . Mahlet A. Woldeyes, Wei Qi, Vladimir I. Razinkov, 2019

机译：低浓度蛋白质相互作用如何预测单克隆抗体的溶液粘度？

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Systematic Investigation of Factors Affecting the Viscosity and Self-Association Issues in High Concentration Monoclonal Antibody Solutions

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