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Double-transfected cell line useful for the identification of transport inhibitors
Double-transfected cell line useful for the identification of transport inhibitors
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机译:双转染细胞系可用于鉴定转运抑制剂
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摘要
Described is a double-transfected cell line containing (a) a DNA sequence encoding an uptake transporter for organic anions, preferably OATP8, operatively linked with a promoter and (b) a DNA sequence encoding an export pump for organic anions or anionic conjugates, preferably the multidrug resistance protein 2 (MRP2), operatively linked with a promoter. Moreover, various uses of said cell line are described, preferably its use for the identification of transport inhibitors, e.g. drug candidates.
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