METHODS FOR PREPARING RUTHENIUM PHOSPHINE COMPLEXES WITH A STRUCTURE CONTAINING PICOLINATE AND/OR DIIMINE AND/OR BIPHOSPHINE IONS, RUTHENIUM PHOSPHINE COMPLEXES OBTAINED BY THESE METHODS AND USES THEREOF

摘要

The invention relates to the synthesis and characterisation of ruthenium(II) phosphine complexes containing picolinate and/or diimine and/or biphosphine ions and having an outstanding pharmacological activity for inhibiting the growth of tuberculosis mycobacteria. These complexes can first be used in the chemical industry, and in the medium and long term, in the pharmaceutical industry. The invention also describes how the activity against tuberculosis bacillus was determined, and how the toxicity of the complexes against macrophage cells within which the tuberculosis bacillus grows was assessed.