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Cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid, useful as intermediate in the preparation of cannabinoid CB1 neutral antagonists
Cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid, useful as intermediate in the preparation of cannabinoid CB1 neutral antagonists
The present invention relates to a cinchonidine salt of (4S,5S)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-4,5-dihydro-1H-pyrazole-3-carboxylic acid. This cinchonidine salt is prepared by enantiomeric resolution of a compound of formula (I) comprising:the reaction of compound of formula (I) with cinchonidine in a suitable solvent, thereby resulting in the cinchonidine salt of the enantiomer (4S,5S) of formula (II); and optionally isolating said salt. The cinchonidine salt according to formula (II) is a useful intermediate in the preparation of a cannabinoid CB1 neutral antagonist.
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机译:本发明涉及(4S,5S)-5-(4-氯苯基)-1-(2,4-二氯苯基)-4-甲基-4,5-二氢-1H-吡唑-3-羧酸的辛可尼定盐酸。该辛可尼定盐是通过对映体拆分式(I)的化合物制备的,该化合物包括: <图像文件=“ IMGA0001.GIF” he =“ 57” imgContent =“ chem” imgFormat =“ GIF” wi =“ 60” /> Chemistry>使式(Ⅰ)化合物与辛可尼定在合适的溶剂中反应,从而得到式(Ⅱ)对映体(4S,5S)的辛可尼定盐;并任选地分离所述盐。式(Ⅱ)的辛可尼定盐是制备大麻素CB 1 Sub>中性拮抗剂的有用中间体。
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