VACCINIUM ULIGINOSUM L. EXTRACT WHICH ENHANCES CELL TRANSDUCIBILITY OF SUPEROXIDE DISMUTASE FUSION PROTEIN

摘要

PURPOSE: A Vaccinium uliginosum L. extract which enhances intracellular introducing ability of SOD fusion protein is provided to enhance intracellular activity and to treat various diseases. CONSTITUTION: A Vaccinium uliginosum L. extract enhances cell permeability of cell permeable superoxide dismutase fusion protein. The Vaccinium uliginosum L. extract is an anthocyanin fraction. A protein transport domain is an HIV-1 Tat(49-57), Tat(51-57), Tat(50-56), Tat(50-57), Tat(50-55), oligo arginine having 5-12 arginine residues, oligolysine having 5-12 lysine residues, or 5-12 arginine. A pharmaceutical composition which is useful for SOD-dependent diseases contains a cell permeable SOD fusion protein and pharmaceutically acceptable carrier containing Vaccinium uliginosum L. extract.