METHOD FOR DIAGNOSING CHRONIC MYELOGENOUS LEUKEMIA UISNG QUANTITIVE MASS SPECTROMETRY

摘要

PURPOSE: A quantitive mass spectrometry of Bcr/Abl hybrid protein is provided to diagnose chronic myelogenous leukemia.;CONSTITUTION: A peptide composition for quantitive measurement of Abl or Bcr/Abl hybrid protein phosphorylation contains a peptide having phosphorylated tyrosine residue of peptide sequence of sequence number 1 or 2. Valine, isoleucine, lysine, or leucine among the peptides is substituted with an isotope. A method for quantitively measuring phosphorylation of Abl or Bcr/Abl hybrid protein comprises a step of using the peptide composition.;COPYRIGHT KIPO 2012