NQO-1, A MARKER FOR DIAGNOSING CUTANEOUS SQUAMOUS CELL CARCINOMA AND USES THEREOF

摘要

The present invention relates to NQO-1, a diagnostic or prognostic marker for squamous cell carcinoma, and a use thereof, and more particularly, to a squamous cell comprising an agent for measuring the expression level of mRNA of NQO-1 (quinone oxidoreductase-1) gene or a protein thereof. Expression of the NQO-1 gene or the coding of the gene from a sample for diagnosing or prognostic cell cancer, a kit for diagnosing or prognostic squamous cell cancer comprising the composition, a patient suspected of squamous cell carcinoma or a patient diagnosed with squamous cell carcinoma Measuring the level of protein; And comparing the expression level of the gene or the level of the protein encoded by the gene with the expression level or protein level of the corresponding gene in the normal control sample. Patients suspected of squamous cell cancer and methods of screening for squamous cell cancer, comprising measuring the expression level of the NQO-1 gene or the protein encoding the gene after administration of a substance expected to be treated Or measuring the expression level of the NQO-1 gene or the protein encoded by the gene from a sample of a squamous cell cancer confirmed patient; And comparing the expression level of the gene or the level of the protein encoded by the gene with the expression level or protein level of the gene of the normal control sample.