Blood protein glycosylation variants in Chiapas Laboratories

摘要

The present invention provides a reduced or which can produce a protein having a modified glycosylation, blood teeth (Pichia) in, especially, blood Chiapas pastoris (Pichia pastoris) genetically methyl nutritional yeast operation comprising the strain . A method for producing a glycoprotein having a blood teeth (Pichia) in the oil reduced by using the operation entirely or strain and / or modified glycosylation also provided. The invention also provides vectors comprising methyl nutritional traits for the conversion of the yeast α-1,2- manno let kinase I, glucosidase II, GlcNAc- transferase I and manno let Kinase II or including decay OCH1 sequence . Kits are also included in the invention minutes to provide the intended vector.