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Process for preparing hyaluronic acid-peptide conjugate, and hyaluronic acid-peptide conjugate produced thereby
Process for preparing hyaluronic acid-peptide conjugate, and hyaluronic acid-peptide conjugate produced thereby
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机译:透明质酸-肽缀合物的制备方法以及由此制备的透明质酸-肽缀合物
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摘要
PURPOSE: A method for preparing hyaluronic acid-peptide conjugate is provided to apply to a drug delivery system of various peptide active ingredients with safety to human body. CONSTITUTION: A method for preparing hyaluronic acid-peptide conjugate comprises: a step of reacting tetra-n-butyl ammonium hydroxide(TBA-OH) with hyaluronic acid(HA), salt thereof, derivative thereof to form HA-TBA; a step of preparing water-insoluble peptide with terminal amino group; and a step of reacting the water-insoluble peptide with HA-TBA and terminal amino group under the presence of organic solvent.
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