MEANS FOR PREVENTION OR TREATMENT OF ALCOHOL DEPENDENCE AND DEPENDENCE ON MEDICINES

摘要

1. An agent for the prevention or treatment of substance abuse and dependence on psychoactive substances, which contains a compound represented by formula (I)! ! where R1 is! (1) hydrogen,! (2) lower alkyl,! (3) lower alkenyl,! (4) -C (O) -lower alkyl,! (5) -C (O) O-lower alkyl,! (6) -C (O) -phenyl (the phenyl group may be substituted with lower alkyl, halogen, lower alkoxy, phenoxy or benzyloxy),! (7) lower alkyl carboxyl,! (8) lower alkyl-C (O) -phenyl (the phenyl group may be substituted with lower alkyl, halogen, lower alkoxy group, phenoxy group or benzyloxy group),! (9) lower alkyl-C (O) O-lower alkyl,! (10) lower alkenyl-C (O) O-lower alkyl,! (11) lower alkyl-O-lower alkyl,! (12) lower alkyl-C (O) NR3R4,! (13) -S (O) 2-lower alkyl,! (14) -S (O) 2-phenyl (the phenyl group may be substituted with lower alkyl, halogen, lower alkoxy group, phenoxy group or benzyloxy group),! (15) lower alkyl-S-lower alkyl,! (16) lower alkyl-S (O) -lower alkyl,! (17) lower allyl-S (O) 2-lower alkyl,! (18) lower alkyl-S (O) 2NR3R4,! (19) phenyl (the phenyl group may be substituted with lower alkyl, halogen, lower alkoxy, phenoxy or benzyloxy) or! (20) benzyl (the phenyl group may be substituted with lower alkyl, halogen, lower alkoxy, phenoxy or benzyloxy),! R2 is hydrogen, lower alkyl, halogen, lower alkoxy, phenoxy, benzyloxy, trifluoromethyl, nitro, amino or cyano,! R3 and R4 may be the same or different, and each of them is hydrogen, lower alkyl or lower alkenyl, or R3 and R4 can