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MULTIPLEX DETECTION OF TUMOR CELLS USING THE PANEL OF AGENTS CONNECTING WITH EXTRAcellular MARKERS
MULTIPLEX DETECTION OF TUMOR CELLS USING THE PANEL OF AGENTS CONNECTING WITH EXTRAcellular MARKERS
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机译:利用与细胞外标志物连接的试剂盒进行肿瘤细胞的多重检测
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摘要
1. A method for detecting cancer cells or cancer cell elements in a biological sample, comprising! i) adding to the specified biological sample a panel of agents that bind to two or more different extracellular markers, where at least one of the agents is cancer specific,! ii) flow cytometry of the obtained biological sample. ! 2. The method according to claim 1 for the detection of disseminated in the tissues of cancer cells. ! 3. The method according to claim 1 or 2 for detecting cancer cells in the lymphatic system. ! 4. The method according to claim 3 for detecting cancer cells in the signal or draining lymph nodes. ! 5. The method according to any one of the preceding paragraphs, where cancer cells are detected with a sensitivity of 90% or more, such as, for example, 91% or more, 92% or more, 93% or more, 94% or more, 95% or more, 96% or more, 97% or more, 98% or more, or 99% or more, or 100%. ! 6. The method according to any one of the preceding paragraphs, in which cancer cells are detected with a specificity of 95% or more, such as, for example, 96% or more, 97% or more, 98% or more, or 99% or more, or 100% which means that 95% or more, such as 96% or more, 97% or more, 98% or more, or 99% or more, or 100% of signal or draining lymph nodes that do not contain cancer cells, will be correctly diagnosed as negative. ! 7. The method according to any one of the preceding paragraphs, in which cancer cells are detected with a negative predictive value of 90% or more, such as, for example, 91% or more, 92% or more, 93% or more, 94% or more, 95% or more, 96% or more, 97% or more, 98% or more, or 99% or more, or 100%. ! 8. The method according to any one of the preceding pu
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