8-OXYCHINOLINE DERIVATIVES AS BRAKININ V2 RECEPTOR MODULATORS

摘要

1. The compound of formula (I)! ! or a pharmacologically acceptable salt, solvate or hydrate thereof, where! A is a 6-membered heteroaryl having from 1 to 3 heteroatoms, each of which is independently selected from N or O, wherein said 6-membered heteroaryl is substituted by from 2 to 4 substituents, each of which is independently selected from a halogen atom, an oxygen atom, hydroxy, cyano, amino, nitro, mercapto, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroalkyl; ! R5 represents a halogen atom, hydroxy, cyano, nitro, mercapto, alkyl, alkenyl, alkynyl or heteroalkyl; ! R6 is optionally substituted alkyl; optionally substituted alkenyl; A 5-membered heterocycloalkyl having 1 to 3 heteroatoms each independently selected from N, O or S, or cycloalkyl, wherein said 5-membered heterocycloalkyl or cycloalkyl is substituted with 0 to 3 substituents, each of which is independently selected from a halogen atom an oxygen atom, hydroxy, cyano, amino, nitro, mercapto, alkyl, alkenyl, alkynyl, heteroalkyl, cycloalkyl, heterocycloalkyl, alkylcycloalkyl, heteroalkylcycloalkyl, aryl, heteroaryl, aralkyl or heteroalkyl; A 5-membered heteroaryl having from 1 to 4 heteroatoms, each of which is independently selected from N, O, or S, wherein said 5-membered heteroaryl is substituted with from 0 to 3 substituents, each of which is independently selected from a halogen atom, an oxygen atom, hydroxy , cyano, amino, nitro, mercapto, alkyl, alkenyl, alkynyl, heteroalkyl, optionally substituted aryl or optionally substituted hetero