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USE OF BUBUC AND OPTIONAL EAA-MARTI (26-35) AS A THERAPEUTIC FOR THE TREATMENT OF HCMV INFECTIONS

机译:使用BUBUC和可选的EAA-MARTI(26-35)作为治疗HCMV感染的疗法

摘要

1. The combination of the peptides Tyr-D-Cys (tBu) -Gly-Phe-Leu-Thr (tBu) -OH and Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val-OH or their salts or hydrates. ! 2. The combination according to claim 1, where the peptides are contained in combination in an amount of from 30 wt.% To 70 wt.% To 70 wt.% To 30 wt.%. ! 3. The combination according to claim 1 for use in medicine. !four. The use of the Tyr-D-Cys (tBu) -Gly-Phe-Leu-Thr (tBu) -OH peptide or a combination according to claim 1, 2, or 3 for the preparation of a pharmaceutical composition for the treatment and / or prevention of a malignant tumor, autoimmune diseases fibrosis, inflammatory diseases, neurodegenerative diseases, infectious diseases, lung diseases, heart and blood vessel diseases and metabolic diseases. ! 5. The use of the peptide according to claim 4, where the malignant tumor, autoimmune disease, fibrosis, inflammatory disease, neurodegenerative disease, infectious disease, lung disease, heart and blood vessel disease or metabolic disease are selected from HBV infection, human cytomegalovirus infection, diseases associated with human cytomegalovirus infection, and also due to HCMV infection in patients with immune deficiency, in transplant organ recipients, in patients undergoing hemodialysis, in cancer patients, in patients receiving immunosuppressive drugs, and in HIV-infected patients, and in patients suffering from pneumonia, gastrointestinal disease, retinal disease, neurological disease, hearing loss, visual impairment, liver failure and colitis, indicated higher diseases in patients with immune deficiency, in transplant recipient recipients, in patients with
机译:1.肽Tyr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH和Glu-Ala-Ala-Gly-Ile-Gly-Ile-Leu-Thr-Val-OH的组合或其盐或水合物。 ! 2.根据权利要求1的组合,其中所述肽的组合含量为30重量%至70重量%至70重量%至30重量%。 ! 3.根据权利要求1的组合,用于医学。四。 4.权利要求1、2或3的T​​yr-D-Cys(tBu)-Gly-Phe-Leu-Thr(tBu)-OH肽或其组合在制备用于治疗和/或治疗的药物组合物中的用途。或预防恶性肿瘤,自身免疫性疾病的纤维化,炎性疾病,神经退行性疾病,感染性疾病,肺部疾病,心脏和血管疾病以及代谢性疾病。 ! 5.根据权利要求4的肽的用途,其中所述恶性肿瘤,自身免疫性疾病,纤维化,炎性疾病,神经退行性疾病,感染性疾病,肺部疾病,心脏和血管疾病或代谢性疾病选自HBV感染,人巨细胞病毒感染,与人巨细胞病毒感染有关的疾病以及免疫缺陷患者,移植器官接受者,接受血液透析的患者,癌症患者,接受免疫抑制药物的患者以及感染了HIV的患者以及由于HCMV感染引起的疾病患有肺炎,胃肠道疾病,视网膜疾病,神经系统疾病,听力损失,视力障碍,肝衰竭和结肠炎的患者在免疫缺陷患者,移植受者中,

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