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METHOD OF BONE RESORPTION TO REMODELLING ANALYSIS
METHOD OF BONE RESORPTION TO REMODELLING ANALYSIS
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机译:骨重塑方法的重塑分析
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摘要
FIELD: medicine.;SUBSTANCE: invention refers to medicine, namely to biochemistry, surgery and dentistry. The bone resorption to remodeling analysis is based on the biochemical blood examination. An the blood coefficient K1 is calculated by formula: K1=[(PTH:A)+(TNF-α:B)+(IL-1β:C)]:3, where PTH is the parathyroid hormone concentration (pg/ml) in the patients, A is the same value in healthy individuals, TNF-α is the level of tumor necrosis factor -α (pg/ml) in the patients, B is the same value in healthy individuals, IL-1β is the interleukin-1β concentration (pg/ml) in the patients, C is the same value in healthy individuals to derive the blood coefficient K2 by formula: K2=[(calcitonin: D) + (osteocalcin: E)]:2, where the calcitonin concentration (ng/ml) in the patients, D is the same value in healthy individuals, the osteocalcin level (ng/ml) in the patients, E is the same value in healthy individuals. Then the bone metabolism control coefficient (BMCC) is calculated by formula BMCC=K1:K2, and the higher BMCC than 1.17, the more intensive resorption prevails over remodelling; and the lower BMCC than 0.83, the more intensive remodelling prevails over resorption.;EFFECT: method allows high accuracy detection of prevalence of resorption or remodelling intensity in the bone stock metabolism control in practically healthy individuals (monitoring) and in pathology cased for the purpose of diagnosis, assessment and therapeutic prognosis.;5 tbl, 3 dwg, 2 ex
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