ISOQUINOLINE AND BENZOHISOQUINOLINE DERIVATIVES, THEIR OBTAINING AND THEIR APPLICATION IN THERAPY AS ANTAGONISTS OF HISTAMINE H₃ RECEPTOR

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: claimed invention relates to compound of formula I in which cycle A represents unsaturated carbocycle with double bonds, which is selected from phenyl or naphtyl; 1 can take value from 1 to 3; m can take value 0, 2 or 3; n can take value 0 or 2; R1 represents a hydrogen atom, (C_1-3)alkyl group; R2 represents(C_1-6)alkyl group, which is possibly substituted with substituent, selected from C₆-cycloalkyl, monocyclic heteroaryl, selected from thiophene, aryl group, selected from phenyl, in form of base or salt of bonding with an acid. Invention also relates to pharmaceutical composition, based on formula I compound, to application of formula I compound for obtaining medication, to method of obtaining formula I compound and to application of formula compound for obtaining formula 1 compound.;EFFECT: obtained are novel isoquinoline and benzo[h]isoquinoline derivatives, possessing properties of antagonists of histamine type H₃ receptor.;9 cl, 1 tbl, 6 ex