ADJUVANT COMPOSITION CONTAINING 3-O-DEACYLATED 4′-MONOPHOSPHORYL LIPID A

摘要

FIELD: medicine, pharmaceutics.;SUBSTANCE: invention concerns microbiology and immunology. An adjuvant composition of 3-O-deacylated 4'-monophosphoryl lipid A (3D-MLA), contains at least 20 mole % of hexa-acyl version which is extracted from Salmonella bacteria, particularly Salmonella minnesota R595.;EFFECT: use of the declared composition allows preserving or increasing immunopotentiating properties and lowering toxicity.;6 cl, 6 ex, 3 tbl, 1 dwg