USE OF 3-O-DEACYLATED MONOPHOSPHORYL LIPID A OR MONOPHOSPHORYL LIPID A IN COMBINATION WITH GM-CSF OR IL-12 AS ADJUVANT COMBINATION IN ANTIGENIC COMPOSITION FOR ENHANCING IMMUNE RESPONSE IN VERTEBRATE

摘要

The use of 3-O-deacylated monophosphoryl lipid A or monophosphoryl lipid A and derivatives and analogs thereof, in combination with a cytokine or lymphokine such as granulocyte macrophage colony stimulating factor or interleukin-12 is useful as an adjuvant combination in an antigenic composition to enhance the immune response in a vertebrate host to a selected antigen.