Preparing substituted aromatic compound, comprises reacting a hydrocarbon compound with a carbonyl compound, an alcohol, an electron-rich aromatic compound and oxygen in the presence of an acid

摘要

Preparing substituted aromatic compound (A) under formation of a carbon-carbon-bonding or a carbon-oxygen-bonding, comprises reacting hydrocarbon compound (I) with a carbonyl compound (IIa), an alcohol (IIb), an electron-rich aromatic compound (IIc) and oxygen in the presence of an acid. Preparing substituted aromatic compounds under formation of a carbon-carbon-bonding or a carbon-oxygen-bonding, comprises reacting hydrocarbon compound of formula (AR-CH-R1R2) (I) with a carbonyl compound of formula (R3-R4CH-CO-R5) (IIa), an alcohol of formula (R6-OH) (IIb), an electron-rich aromatic compound of formula (Phen-(1-6C-alkoxy) n) and oxygen in the presence of an acid. either AR : (hetero)aromatic residue, which is optionally substituted; and R1, R2 : H, OH, F, Cl, Br, I, CN, NO 2, NO, SO 2, SO 3H, NH 2, PH 3, COOH, SO 3X, COOY, 1-20C alkyl, 2-20C alkenyl, 2-20C alkynyl, aryl, aryl-(1-6C) alkyl, hetero (1-6C)-alkyl or heteroaryl residue, which is optionally substituted; or R1+Ar or R2+Ar : ring; X, Y : Na or K; either R3, R4 : H, 1-6C alkyl, 1-6C alkenyl, aryl, heteroaryl, 3-6C cycloalkyl, 1-6C alkoxy or CO-R7; or R3+R5 or R4+R5 : ring system; R6 : H, 1-6C alkyl, 1-6C alkenyl, aryl, heteroaryl, 3-6C cycloalkyl, 1-6C alkoxy or CO-R5; R5 : H, 1-6C alkyl, 1-6C alkoxy, 1-6C-S-alkyl, 1-6C-alkenyl, aryl, -O-aryl,-S-aryl, heteroaryl, 3-6C cycloalkyl, NR8R9; R7 : R5 (each of which is optionally substituted); R8, R9 : H, optionally substituted 1-6C alkyl, benzyl or aryl; Phen : phenyl, where two of the substituents are arranged in the para-position; and n : 2 or 3.