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combination of fosfomycin / aminoglycosid in aerosolform for the treatment of bacterial respiratory infections
combination of fosfomycin / aminoglycosid in aerosolform for the treatment of bacterial respiratory infections
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机译:磷霉素/氨基糖苷在气雾剂中的组合治疗细菌性呼吸道感染
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摘要
A fosfomycin plus tobramycin combination formulation for delivery by aerosolization is described. The concentrated fosfomycin tobramycin combination formulation containing an efficacious amount of fosfomycin plus tobramycin is able to inhibit susceptible bacteria. Fosfomycin and tobramycin are formulated separately in a dual ampoule such that when reconstituted, the pH is between 4.5 and 8.0 or as a dry powder. The method for treatment of respiratory tract infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 µ, produced by a jet or ultrasonic nebulizer (or equivalent) or dry powder inhaler.
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