CREATING POULTRY AND OTHER ANIMALS RESISTANT TO VIRAL DISEASE

摘要

PROBLEM TO BE SOLVED: To provide germ cells encoding for siRNA that is a target viral sequence and methods for obtaining the same.SOLUTION: The invention is related to genetically modified animals which are resistant to viral infections. Also provided are methods for creating animals which are resistant to viral infection. The invention is a germ cell of a non-human vertebrate containing a construct comprising a sequence encoding an siRNA to a conserved region of a viral genome, wherein the sequence is operably linked to a promoter. The invention provides for a non-human vertebrate that is resistant to a viral disease, wherein the majority of cells in the vertebrate comprise a sequence encoding an siRNA to a conserved region of a genome of a virus causative of the disease, wherein the sequence is operably linked to a promoter.