Manufacturing methods and new oligosaccharide of oligosaccharides and pharmaceutical compositions containing it

摘要

PROBLEM TO BE SOLVED: To readily obtain the subject compound containing a galactose residue at a reduction end group by subjecting a protected hydroxyl group and a protected amino group in glucosamine and a protected hydroxyl group in galactose to glucoside bond reaction. ;SOLUTION: A monosaccharide of formula I (R1 and R2 are each an aralkyl; R3 is an acyl or silyl; R4 is an amino-protecting group; R5 is an eliminable group) and a monosaccharide of formula II (R6 and R8 are each an aralkyl; R7 is an acyl or silyl; R9 is an aralkyl, 6-O-sulfated N-acetylglucosamine residue, an alkyl, a glycerol residue, or the like; Z is O or NHCO) are subjected to glycoside bond reaction to give an oligosaccharide of formula III (R10 and R11 are each H, an SO3M (M is proton or a monofunctional cation); Ac is acetyl; R12 is H, 6-O-sulfated N-acetylglucosamine residue; an alkyl, a glycerol residue, or the like). A part of the oligosaccharide of formula III is useful as an antiallergic agent or an antiinflammatory agent.;COPYRIGHT: (C)2000,JPO