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Use of 4-hydroxy tamoxifen in the manufacture of drugs for the treatment of gynecomastia
Use of 4-hydroxy tamoxifen in the manufacture of drugs for the treatment of gynecomastia
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机译:4-羟基他莫昔芬在生产用于治疗男性乳房发育症的药物中的用途
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摘要
The present invention provides methods for treating and preventing gynecomastia by administering 4-hydroxy tamoxifen to a patient. When percutaneously administered to a patient's breasts, 4-hydroxy tamoxifen concentrates locally, and exerts an anti-estrogenic effect. In patients with gynecomastia, this reduces the effective estrogen-androgen ratio in the breast tissue, thereby reducing ductal proliferation, epithelial and stromal hyperplasia, and pain. In patients at risk for developing gynecomastia, 4-hydroxy tamoxifen's anti-estrogenic effect prevents tissue proliferation and its accompanying pain.
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