The efficacy of tamoxifen in the treatment of primary gynecomastia: An observational study of tamoxifen versus observation alone

摘要

Gynecomastia is a common condition defined as overdevelopment of male breast tissue resulting from a relative overactivity of estrogen (1). It may be primary or secondary to drug use, liver disease, chronic renal failure, malignancy or genetic disorders (1-3). Although most gynecomastia is asymptomatic, it can result in a painful, unsightly swelling behind the are-ola, which leads some men to pursue diagnosis and treatment (4). We present an observational study of the effects of tamoxifen and observation alone in the treatment of gynecomastia.