3,6-substituted 5-arylamino-1H-pyridin-2-one derivatives and related compounds as poly (ADP-ribose) polymerase (PARP) inhibitors in the treatment of tissue damage or disease caused by necrosis or apoptosis

摘要

This invention relates to compounds of formula (I), wherein R1 and R3 independently represent fluorine, methoxy, OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; R2 represents hydrogen, fluorine, methoxy, OCF3, C2-C3-alkenyl or C1-C4-alkyl which is optionally substituted by chlorine, methoxy or one, two or three fluorine atoms; X represents O, S, NH or N(C1-C3-alkyl); and Ar represents an unsubstituted or at least monosubstituted aryl or heteroaryl. Said compounds are inhibitors of poly(ADP-ribose) polymerase (PARP), and may be used for the treatment of a variety of disorders.