The use null for the high throughput screening of manner, and the interest target numerator which identify the ligand qualification the functional cascade where the target participates choice

摘要

As for this invention, method in order to identify the ligand which can decorate the functional cascade where the target participates selectively, and the molecule of the interest object and the molecule in regard to especially remedy (the medicine) it regards the use for the high throughput screening. The above-mentioned method includes the following process at least: a) it can connect to the above-mentioned target and it can decorate the above-mentioned functional cascade where the said target participates, the antibody or antibody fragment which includes at least one of variable domain of the immunoglobulin chain is identified; b) from the group of the molecule, the ligand which decorates the connection with the above-mentioned target and a) with the antibody or antibody fragment which is identified the screening is done; And c) b) with among the decoration characteristic ligands which are obtained, those which can decorate the above-mentioned functional cascade are identified. Selective figure It is not