Means for the detection and purification of CD8 + T lymphocyte populations specific for peptides presented in the context of HLA

摘要

The invention concerns multimers developed from recombinant proteins analogues of MHC class I, characterised in that the proteins comprise at least an alteration in the zone of interaction of a heavy chain with the T-cell co-receptor CD8 leading to a reduction, even the suppression of the affinity of the interaction between the heavy chain and CD8. Said multimers forming complexes with antigenic peptides are useful for diagnostic and therapeutic purposes.