Disclosed are peptides having SEQ ID NOs: 1 to 24 that induce superoxide generation by human monocytes or neutrophils; that induce an intracellular calcium increase by human peripheral blood monocytes or neutrophils; binds to formyl peptide receptor or formyl peptide receptor-like 1; that induce chemotactic migration of human monocytes or neutrophils in vitro; that induce degranulation in formyl peptide receptor expressing cells or formyl peptide receptor-like 1 expressing cells; that stimulate extracellular signal regulated protein kinase phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1; or that stimulate Akt phosphorylation via activation of formyl peptide receptor or formyl peptide receptor-like 1.
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机译:公开了具有SEQ ID NO:1至24的肽,其诱导人单核细胞或嗜中性粒细胞产生超氧化物。通过人外周血单核细胞或中性粒细胞诱导细胞内钙增加;与甲酰肽受体或甲酰肽受体样1结合;在体外诱导人单核细胞或中性粒细胞趋化性迁移;在表达甲酰基肽受体的细胞或表达甲酰基肽受体的细胞中诱导脱粒;通过甲酰肽受体或甲酰肽受体样1的激活刺激细胞外信号调节的蛋白激酶磷酸化;或通过甲酰肽受体或甲酰肽受体样1的激活刺激Akt磷酸化。
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