The nuclear acid of C die hepatitis virus origin and the manifestation vector which uses that, the transformation cell and C die hepatitis virus grain

摘要

As for this invention, 5 ' the untranslation region of C die hepatitis virus genome, the NS3 protein code field, the NS4A protein code field, the NS4B protein code field, the NS5A protein code field and the NS5B protein code field and 3 ' being the nuclear acid which includes the untranslation region, In the aforementioned NS3 protein code field, the aforementioned NS5A protein code field or the aforementioned NS5B protein code field, M (1205) K and F in the case where the amino acid array which is shown with array number 6 in the array table is made standard array (1548) L, C (1615) W and T (1652) N and A (2196) T and A (2218) S and H (2223) Q and Q (2281) R and K (2520) N and G (2374) it possesses the base displacement which causes the amino acid displacement of 1 or more where it is chosen from the group which consists of S, nuclear acid is offered.