By arrangement designed so as to form the intrastrand base pairing, and increased expression of the heterologous nucleotide sequence of one strand of the recombinant viral vector

摘要

Recombinant viral vectors, especially parvovirus such as adeno-associated virus (AAV) vectors, capable of enhanced expression of heterologous sequences, and methods for their construction and use, are provided. The vectors have a structure, or are capable of rapidly adopting a structure, which involves intrastrand base pairing of at least one region in a heterologous sequence.