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Glycolipid-containing compound, the detection method of the detection reagent and the sugar-binding compound containing the immobilized biosensor, glycolipid-containing fine particles, the fine particles that
Glycolipid-containing compound, the detection method of the detection reagent and the sugar-binding compound containing the immobilized biosensor, glycolipid-containing fine particles, the fine particles that
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机译:含糖脂的化合物,检测试剂的检测方法和包含固定化的生物传感器的糖结合化合物,含糖脂的微粒,
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摘要
[Challenge] the present invention, can be to fine particle surface or the surface of the substrate sugar compound, to be fixed easily at a high density and a high degree of orientation, yet be quantitatively evaluated the sugar-binding compound easily and quickly with high sensitivity It is an object of the present invention is to provide a sugar-containing compound makes it possible. The present invention aims to provide a method of detecting the sugar-binding compound sensor, or detection reagents, can be quantitatively evaluated the sugar-binding compound easily and rapidly with high sensitivity. Following formula glycolipid-containing compound according to [SOLUTION] The present invention is, (1) Wherein, (N is an integer of 1 to 10) shows the sugar chain portions of sugar covalently bonded to a linear or branched G N is the N; X represents -NH- or -O-; -C -CH Or (= O) -C n H 2n -Y 2 -C n H 2n -Y (wherein, n represents an integer of 2~10, R 1 is one or two or more of Y indicates a linker moiety that can be represented by) a group having a disulfide group two or one or more thiol groups.; R 2 is preferably C 1~21 alkyl which may have C 2~20 alkenyl group, a substituent which may have C 2~20 alkyl group or a substituted group may have a substituent The substituted or 2-21 alkenylcarbonyloxy methyl group, a C which may have 2-22 alkyloxymethyl group optionally C, and substituents which may have carbonyloxy methyl group, the substituent I show a side chain moiety that can be represented by 2-22 alkenyloxy methyl group C is also good. It is characterized by being represented by the formula.
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机译:[挑战]本发明可以是细颗粒表面或底物糖化合物的表面,易于以高密度和高取向度进行固定,但可以容易,快速地定量评价糖结合化合物。高灵敏度本发明的一个目的是提供一种使含糖化合物成为可能。本发明旨在提供一种检测糖结合化合物传感器的方法或检测试剂,其可以容易且快速地以高灵敏度定量评估糖结合化合物。根据[SOLUTION],下式为含糖脂的化合物:(1)其中,(N为1至10的整数)表示共价键合至直链或支链G N的糖的糖链部分 Sub>是N; X代表-NH-或-O-; -C -CH或(= O)-C n Sub> H 2n Sub> -Y 2 Sub> -C n Sub> H < Sub> 2n Sub> -Y(其中,n表示2〜10的整数,R 1 Sup>是Y中的一个或两个或多个表示可表示的连接基)具有二硫键的两个或一个或多个硫醇基。 R 2 Sup>优选为可以具有 C Sub> 2〜20烯基的 C Sub> 1〜21烷基,可以具有 C < / Sub> 2〜20烷基或取代基可具有取代基取代或 2-21 Sub>烯基羰氧基甲基,C可能具有 2-22 Sub>烷氧基甲基任选地C,和可以具有羰氧基甲基的取代基,取代基I显示可以由 2-22 Sub>烯基氧基甲基C表示的侧链部分也是好的。它的特征在于用公式表示。
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