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Method for producing reprogrammed cells using a non-chromosomal viral vector

机译:使用非染色体病毒载体产生重编程细胞的方法

摘要

An object of the present invention is to provide a vector for easily and efficiently producing ES-like cells in which a foreign gene is not integrated into a chromosome. The present inventors have found a method for producing ES-like cells from somatic cells using a non-chromosomal viral vector. Since the prepared ES-like cells do not have foreign genes integrated into their chromosomes, they are not only convenient for testing and research using these cells, but also in the treatment of diseases, the problem of immune rejection and ethical aspects. The problem may be avoided.
机译:本发明的目的是提供一种载体,该载体用于容易且有效地产生其中未将外源基因整合到染色体中的ES样细胞。本发明人发现了使用非染色体病毒载体从体细胞产生ES样细胞的方法。由于制备的ES样细胞没有整合到染色体中的外源基因,因此它们不仅方便了使用这些细胞进行测试和研究,而且还方便了疾病的治疗,免疫排斥问题和道德方面的问题。可以避免该问题。

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