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Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA
Compositions and Methods for Regulating Cytochrome c-Mediated Apoptosis by tRNA
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机译:tRNA调节细胞色素c介导的细胞凋亡的组成和方法
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摘要
The invention relates to the discovery that tRNA is a potent regulator of cell survival, tRNA regulates the interaction between cytochrome c and Apaf-1 and subsequently Apaf-1 oligomerization into an apoptosome which in turn recruits and oligomerizes the caspase cascade which ultimately leads to cell death. Accordingly, the present invention provides compositions and methods for regulating cell survival.
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