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Methods for Identifying Factors That Control the Folding of Amyloid Proteins of Diverse Origin
Methods for Identifying Factors That Control the Folding of Amyloid Proteins of Diverse Origin
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机译:识别控制多种来源淀粉样蛋白折叠的因素的方法
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摘要
The present invention provides a yeast cell based system for determining factors that control the folding of amyloid proteins of diverse origins. Further the present invention provides methods of using such a system to screen for reagents that affect amyloid formation, a process that is integral to several devastating human disease including Creutzfeld-Jacob disease (CJD), fatal familial insomnia (FFI), Gertsmann-Straussler-Scheinker (GSS) syndrome, and kuru. The system of the present invention provides a rapid screening system to quickly and cheaply identify reagents that affect the folding and aggregation properties of the target protein.
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