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Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis
Treatment of drug-related side effect and tissue damage by targeting the CD24-HMGB1-Siglec10 axis
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机译:通过靶向CD24-HMGB1-Siglec10轴来治疗药物相关的副作用和组织损伤
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摘要
The present technology provides methods and compositions for the treatment of tissue-damage related immune dysregulation by administering a composition comprising one or more of CD24; CD24 fragments, variants and derivatives, CD24Fc fusion proteins; HMBG1-binding proteins, binding proteins to HMBG1 Box B; antagonists of HMGB1, polyclonal, monoclonal, recombinant, chimeric, humanized scFv antibodies and antibody fragments to HMGB1 or fragments of HMGB1 and antibodies that bind and suppress the activity of HMGB1 Box B; Siglec 10 agonists such as anti-Siglec 10 antibodies; and combinations thereof to a patient.
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