Gadolinium containing prussian blue nanoparticles as nontoxic MRI contrast agents having high relaxivity

摘要

Gadolinium⁺³ (Gd³⁺) containing (or incorporated) Prussian blue lattice contrast agents that can be used as an MRI contrast agent have unexpectedly improved r₁ relaxivities of 1 or 2 magnitudes higher than the commercial Gd³⁺-chelates as well as exceedingly, non-toxic, low release of the Gd³⁺ ions into an aqueous environment at a pH of about 2 to about 7.5. The Prussian blue lattice containing Gd³⁺ ions therein can be used for clinical diagnosis intravenously to human beings for medical imaging. The particle sizes of the doped Prussian blue lattices are of a nanosize scale and are very stable against agglomeration.