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Procedure for preparing a Polymorph of the choline Salt of (4.6) - bis (dimethylamino) 2 - (4 - ((4 - (trifluoromethyl) - benzoyl amino benzyl) - pyrimidin-2-yl) - yl) 5
Procedure for preparing a Polymorph of the choline Salt of (4.6) - bis (dimethylamino) 2 - (4 - ((4 - (trifluoromethyl) - benzoyl amino benzyl) - pyrimidin-2-yl) - yl) 5
Pharmaceutical composer Requirement 1: a procedure characterized by the preparation of a formulation of a crystalline form of choline salt (1),It includes the following procedures: (a) the first synthesis of a formula salt (1) into a solvent, including isopropanol and water; (b) the first mixture in stage (a) is associated with an anti isopropant to provide a second mixture; Y (c) allows the choline salt of formula compound (1) to crystallize from the second mixture of level (b) to provide the crystalline form of formula compound (1).
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