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Levetiracetam formulations of controlled release and Methods for their production
Levetiracetam formulations of controlled release and Methods for their production
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机译:左乙拉西坦控释制剂及其生产方法
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摘要
Disclosed are Pharmaceutical compositions in the form of Tablets containing Active Ingredients such as levetiracetam Component and a water-soluble Polymer which mainly includes not water-soluble Polymers that comprise between 60% and 100% of the component of the core Polymer Compressed Component Polymer, preferably in the tablet Core.The pharmaceutical compositions may also include a Coating slow release that includes both water-soluble and non water-soluble Polymers.Claim 1: a Pharmaceutical composition in the form of Tablet comprises a Tablet Core which in turn comprises an active ingredient and a water-soluble Polymer Component comprising a water-soluble Polymer not comprising between about 1% and 50% by weight of Dec Ho Tablet Core,Where the water insoluble Polymer comprises between about 60% and 100% of the component of Polymer. Claim 2: the pharmaceutical composition according to claim 3, wherein the slow release Coating comprises a mixture of at least one Water insoluble Polymer and at least one water soluble Polymer.Claim 5: the pharmaceutical composition according to claim 1, wherein Said water-soluble Active Ingredient includes ievetiracetam.Claim 8: the pharmaceutical composition according to claim 1, wherein said not water-soluble Polymer is selected from the group consisting of Ethyl Cellulose, Cellulose acetate, butilcelulosa, Cellulose acetate butyrate, Copolymer of ethylene - vinyl acetate, polividonaceta To polivinilbutirato polymethyl methacrylate Polyvinyl Acetate,,,,Ammonia methacrylate Copolymer, and mixtures thereof. Claim 9: the pharmaceutical composition according to claim 8, wherein the water insoluble Polymer is selected from the group consisting of Ethyl Cellulose, polymethacrylates, Ammonia methacrylate Copolymer, and mixtures thereof.Claim 13: the pharmaceutical composition according to claim 4, wherein Said Coating slow release includes from about 1% and 20% by weight of said Pharmaceutical composition.Claim 16: the pharmaceutical composition according to claim 4, wherein the polymer is not Soluble in said Coating slow release is selected from the group consisting of Ethyl Cellulose, Cellulose acetate, butilcelulosa, Cellulose acetate butyrate, COPOLYMER Ethylene - vinyl acetate, Polyvinyl Acetate, polyvinyl - polividonacetato, butyrate, polymethacrylate,Ammonia methacrylate Copolymer, and mixtures thereof. Claim 17: the pharmaceutical composition according to claim 16, wherein the polymer is not Soluble in said Coating slow release comprising ethylcellulose.Claim 18: the pharmaceutical composition according to claim 4, wherein Said water-soluble Polymer in said slow release Coating is selected from the group consisting of methylcellulose, hydroxypropyl Cellulose, hydroxypropyl Methyl Cellulose, polyvinylpyrrolidone, Polyvinyl alcohol, Polyethylene glycol, and their mixtures.Claim: the pharmaceutical composition according to claim 18, wherein Said water-soluble Polymer in said Coating slow release comprises hydroxypropyl methylcellulose.
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