benzoazepin-oxo acetic acid derivatives as ppar-delta agonists used to increase lower hdl-c, lower ldl-c and lower cholesterol

摘要

BENZOAZEPIN-OXY-ACETIC ACID DERIVATIVES AS PPAR-DELTA AGONISTS USED FOR INCREASING HDL-C, LOWER LDL-C, AND LOWER CHOLESTEROL. The present invention relates to compounds of Formula (1) useful as PPAR agonists. Also described are pharmaceutical compositions and methods of treating one or more conditions including, but not limited to, diabetes, nephropathy, neuropathy, retinopathy, polycystic ovary syndrome, hypertension, ischemia, stroke, irritable bowel disorder, inflammation, cataract, cardiovascular disease, Metabolic Syndrome X, hyper-LDL-cholesterolemia, dyslipidemia (including hypertriglyceridemia, hypercholesterolemia, mixed hyperlipidemia, and hypo-HDL-cholesterolemia), atherosclerosis, obesity, and other disorders related to lipid metabolism and energy homeostasis complications of these using compounds of the invention.