Region-based DNA vaccines will be incorporated into the shell coding of Lamp yellow fever virus and vaccine antigens.

摘要

p THIS INVENTION REFERS TO DNA VACCINES THAT CODIFY FOR SPECIFIC VIRAL SEQUENCES. THE DNA VACCINES AGAINST THE YELLOW FEVER, DEVELOPED ACCORDING TO THE INVENTION, ARE BASED ON THE SEQUENCE CODIFLCING FOR THE PROTECTION OF THE VFA WRAP em (P / /em YFE). ADMINISTRATION OF THE CONSTRUCTION OF NATURAL TYPE P / YFE, THE SEQUENCE AND ALSO FUSIONOacute; WITH THE SEQUENCE THAT CODIFIES FOR THE PROTEIacute; NA ASSOCIATED WITH THE LISOSOacute; MICA HUMAN MEMBRANE (H-LAMP),GENERATING CONSTRUCTION (PL / YFE). THE RESULTS OF THE INVENTION ARE CONSIDERED VERY PROMISING, BECAUSE THE TWO BUILDINGS CAN INDUCE AN ANSWER OF CEacute; LULAS T AGAINST THE SAME EPIacute; TOPOS INDUCIDOS BY THE VACCINE 17DD, AND THE CONSTRUCTION PIE TIP; TO INDUCE NEUTRALIZING ANTIBODIES TO A SATISFACTORY CONSIDERED CONCENTRATION. THE PL / YFE VECTOR IS ALSO INOCULATED; IN MOUSES FOR INTRACEREBRAL EXHIBITION nbsp; BACK WITH VFA. SURPRISINGLY, 100% OF THE IMMUNIZED MOUSES WITH PL / YFE SURVIVED THE EXHIBITION. /p