首页> 外国专利> Solid forms of (2S, 3R, 4R, 5S, 6R) - 2 - (4 - chlorine - 3 - (4 - etoxibencil) phenyl) - or - (methylthio) - tetrahydro 2H - piran - 3,4,5 - triol and Methods for their use

Solid forms of (2S, 3R, 4R, 5S, 6R) - 2 - (4 - chlorine - 3 - (4 - etoxibencil) phenyl) - or - (methylthio) - tetrahydro 2H - piran - 3,4,5 - triol and Methods for their use

机译:(2S,3R,4R,5S,6R)-2-(4-氯-3-(4-依托昔苯酯)苯基)-或-(甲硫基)-四氢2H-吡喃-3,4,5-三醇的固体形式及其使用方法

摘要

This Invention is directed, in part, to Amorphous and Crystalline Solid forms of (2S, 3R, 4R, 5S, 6R) - 2 - (4 - chlorine - 3 - (4 - etoxibencil) phenyl) - 6 - (methylthio) - tetrahydro 2H - piran - 3,4,5 - triol anhydrous, which is an inhibitor The Sodium Glucose Co Transporter Type 2, and may be useful in the treatment of Diabet Is and a variety of other diseases and conditions.This Invention is also directed to dosage forms comprising Solid forms of (2S, 3R, 4R, 5S, 6R) - 2 - (4 - chlorine - 3 - (4 - etoxibencil) phenyl) - 6 - (methylthio) - tetrahydro 2H - piran - 3,4,5 - triol, anhydrous, and with methods for their a modality of use. The Invention encompasses Pharmaceutical compositions Solid forms comprising described here.Another approach is to inhibit the activity sglt2 methods, as well as methods to treat, prevent and handle a variety of diseases and disorders, using solid forms described here.
机译:本发明部分针对(2S,3R,4R,5S,6R)-2-(4-氯-3-(4-依托昔苯酯)苯基)-6-(甲硫基)-的无定形和结晶固体形式无水四氢2H-皮兰-3,4,5-无水三醇,是抑制剂2型葡萄糖钠转运蛋白,可用于治疗糖尿病和多种其他疾病和状况。剂型,包括(2S,3R,4R,5S,6R)-2-(4-氯-3-(4--依托昔苯酯)苯基)-6-(甲硫基)-四氢2H-吡兰-3,4的固体形式,5-无水三醇,及其使用方法。本发明包括药物组合物,其包含本文所述的固体形式。另一种方法是使用本文所述的固体形式抑制sglt2活性方法以及治疗,预防和处理多种疾病和病症的方法。

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