Complexes of copper with 2-phenyl-3-hydroxyquinolin-4(1H)-one derivatives, process of their preparation and use of such complexes as medicaments intended for antitumor therapy

摘要

complexes between in oxidacnu00edm degree + ii and their krystalosolvu00e1ty involving structural motive and the general formula ii or iii vyju00e1drenu00e9ho structural formula [cu (l1), (l2)] (ii) or [cu (l1) (l3).sub.2.n.(iii) where l1 is the symbol of derivative 2 - phenyl - 3 - benzoic acid - 4 (1h) - the general formula ivl2 bidentu00e1tne with coordinating n - donorovu00fd ligand and l3 monodentu00e1tne with coordinating n - donorovu00fd ligand on atom between basic motive, even.where the substituents r1 and r2 are independently selected from the group of: hydrogen atom, alkyl, substituted alkyl, halogen, amino groupkarboxamido group or other operational group or combination of these substituentu, while amino can be further substituovu00e1na as n - ru00b4 - ru00b4u00b4,in which ru00b4 and ru00b4u00b4 independently of each represent hydrogen atom, alkyl, substituted a hydrogen atom, alkyl, substituted alkyl, cycloalkyl, substituted cycloalkyl, cykloheteroalkyl,substituted cykloheteroalkyl, heteroaryl and substituted heteroaryl, while karboxamido group can be further substituovu00e1na like what - n - ru00b4u00b4u00b4 in which ru00b4u00b4u00b4symbolizuje hydrogen atom, alkyl,substituted alkyl, cycloalkyl, substituted cycloalkyl, substituted cykloheteroalkyl, cykloheteroalkyl, heteroaryl and substituted heteroaryl,and l2 and l3 are ligands coordinating to the atom atom or nitrogen atoms in it.