Process for preparing extreme optically pure 2-({(5S)-2-oxo-3-4-(3-oxo-4-morpholinyl)phenyl-1,3oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione

摘要

the solution concerns the way production optically highly pure 2 - ({), 5s) - 2 - oxo - 3 - [4 - (3 - oxo - 4-morpholinyl) phenyl] - 1,3 - oxazolidin - 5 - yl} methyl) - 1h-isoindole-1,3 (2h) - dione, chemical formula ithe reaction of 2 - ((2r) - 2 - hydroxy - 3 - [4 - (3 - oxo - 4-morpholinyl) phenyl) aminopropyl) - 1h-isoindole-1,3 (2h) - dione, chemical formula iii, containing (s) - isomer, chemical formula iiib, with n,n - karbonyldiimidazolem in tetrahydrofuran without the presence of a catalyst, 4 - dimethylaminopyridinu, while reaction is carried out so that it is accomplished in awhen the reactive mixture still contains nezreagovanou substance iii in a quantity which is in the range of 3 to 5 times the original amount of (s) - isomer in nasazovanu00e9 substance iii.