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Process for preparing extreme optically pure 2-({(5S)-2-oxo-3-4-(3-oxo-4-morpholinyl)phenyl-1,3oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
Process for preparing extreme optically pure 2-({(5S)-2-oxo-3-4-(3-oxo-4-morpholinyl)phenyl-1,3oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione
The present invention relates to a process for preparing optically highly pure compound of formula I, reacting 2 - ((2R) -2-hydroxy-3- [4- (3-oxo-4-morpholinyl) phenyl] aminopropyl) -1H-isoindole-1,3 (2H) -dione, the compound of formula III, containing (2S) -isomer, compound of formula IIIb with N, N-carbonyldiimidazole in tetrahydrofuran in the absence of the catalyst 4-dimethylaminopyridine, the reaction being carried out such that it is terminated when the reaction mixture still contains unreacted material III at which is between 3 and 5 times the original volume (2S) -isomer in a feed substance III.
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