Synthesis and antimicrobial evaluation of some 2-[2-(3-methyl-4,5-substituted biphenyl pyrazolo [3,4-c]pyrazol-1(5H)-yl)alkoxy]-1H-isoindole-1,3(2H)-dione

摘要

3-Methylpyrazol-5-one 3 reacted with substituted ben-zaldehydes 4a-c followed by 2-bromoalkoxy-1H-isoin-dole-1,3(2H)-diones 2a-b furnished 2-[2-(4-arylidene-3-methyl-5-oxo-4,5-dihydro-pyrazol-1-yl)alkoxy]-isoindole-1 ,3-diones 6a-f,which on cyclisation with substituted phenyl hydrazine's afforded titled compounds 7a-I.Final compounds were also screened for their antibacterial properties against six bacterial strains in order to obtain chemotherapeutic properties.