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Hydrobromide of 5-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl-4,5,6,7-tetrahydrothieno3,2-cpyridin-2-yl acetate known under unprotected name prasugrel and process for preparing thereof
Hydrobromide of 5-2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl-4,5,6,7-tetrahydrothieno3,2-cpyridin-2-yl acetate known under unprotected name prasugrel and process for preparing thereof
The present invention relates to hydrobromide form B, which is a well-known substance reducing coagulation of blood, prasugrel of the general formula I, exhibiting high chemical stability, further to a process of its preparation comprising dissolution or suspending of a compound of the general formula I in alcohol containing 1 to 4 carbon atoms, in acetic acid alkyl ester having 1 to 4 carbon atoms or in aromatic hydrocarbons or mixtures thereof and the reaction of the compound with hydrobromic acid at a temperature ranging from -15 degC to a solvent boiling point, or in crystallization of prasugrel hydrobromide form A.
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