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IN VITRO USE OF POLYPEPTIDE FACTORS OR FRAGMENT THEREOF AS A DOWNSTREAM TARGET OF A DOWNSTREAM MARKER OF PI3K PATHWAY IN DRUG SCREEN, DESIGN AND DEVELOPMENT
IN VITRO USE OF POLYPEPTIDE FACTORS OR FRAGMENT THEREOF AS A DOWNSTREAM TARGET OF A DOWNSTREAM MARKER OF PI3K PATHWAY IN DRUG SCREEN, DESIGN AND DEVELOPMENT
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机译:多肽因子或其片段的体外使用作为药物屏幕PI3K通路下游标记的下游目标,设计和开发
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摘要
The present invention is related to a nucleic acid coding for a factor involved in a biological process, whereby the process is a PI 3-kinase pathway regulated process, preferably a process selected from the group comprising glucose metabolism, amino acid and glucose deprivation processes, diabetes, wound healing, stress response, apoptosis, metastasis, tumorigenesis, cell migration, cell motility in extracellular matrix and cell growth in extracellular matrix, and the factor is a polypeptide comprising an amino acid sequence according to SEQ ID. NO. 1 or a polypeptide having a sequence according to databank entries gi 9506687 or NP_061931, preferably NP_061931.1.
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